Separation of DNA polymerase from rat liver and hepatomas.
نویسندگان
چکیده
Sephadex G-200 column chromatography of hepatoma DNA polymerase yields two peaks of enzyme activity. Peak I contains enzyme having a marked preference for denatured DNA, and the levels of this enzyme increase in proportion to tumor growth rate. Peak II contains the enzyme fraction having a moderate preference for native DNA. Normal and regenerating rat liver have a predominance of Peak II, in contrast to hepatomas. Peak I has been described as the major peak in fetal rat liver, and the present results are discussed in terms of repression of Peak I in adult liver and derepression which occurs as part of the process of malignant transformation.
منابع مشابه
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عنوان ژورنال:
- Cancer research
دوره 29 8 شماره
صفحات -
تاریخ انتشار 1969